Dr. Sivaprakash Ramalingam, Ph.D

Sivaprakash Ramalingam, Ph.D., is a Senior Scientist, Division of Genomics and molecular medicine at CSIR-Institute of Genomics and Integrative Biology, New Delhi. He received his PhD degree from Center for Biotechnology, University of Madras. After a short stint working in Pharmaceutical Company, Orchid Chemicals and Pharmaceuticals Ltd, as a Research Scientist, he pursued his Post-doctoral training at Johns Hopkins University Medical Institutions, Baltimore, USA, where he began studies on optimizing gene editing of human somatic cells including pluripotent stem cells as a way to treat patients with hematological diseases. He was a Maryland Stem Cell Research Post-doctoral Fellow from 2010-2012 at Johns Hopkins. He joined CSIR-Institute of Genomics and Integrative Biology, New Delhi in 2017 as a Senior Scientist. His lab works on three broad areas in regenerative medicine. The first area is the reactivation of fetal hemoglobin synthesis in patient-derived adult hematopoietic stem progenitor cells using targeted genome-engineering approach for the treatment of beta-hemoglobin disorders. The second of this is identification of fetal hemoglobin associated genetic variants/modifiers for disease severity of sickle cell disease (SCD) and ?-thalassemia phenotype using genomic technologies. The third area is generation of induced pluripotent stem cell-derived organoid model to recapitulate pathological hallmarks of nephrological and lysosomal storage disorders. He has co-authored 20 research articles in peer-reviewed journals mostly in the field of genome editing and stem cells. He receives grant supports from various funding agencies in India.

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